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目的观察健脾调中散对功能性消化不良患儿的临床疗效及其改善胃肠动力障碍的作用。方法 90例选择功能性消化不良患儿随机分为试验组和对照组,各45例。试验组口服健脾调中散,5~9岁患儿每次10 m L;10~14岁患儿每次20 m L,早晚餐后1 h服用;对照组口服多潘立酮混悬液,5~7岁5 m L;8~10岁7.5 m L;11~14岁10 m L。治疗1个月后,比较2组患儿治疗前后临床主要症状、胃电图、血胃动素、生长抑素以及胃泌素的变化。结果治疗后,试验组的总有效率为86.67%,显著高于对照组的75.56%(P<0.05)。治疗后,试验组腹痛、腹胀、食少早饱、恶心呕吐临床症状改善显著优于对照组(P<0.05)。治疗后空腹正常胃电节律百分比,显著高于治疗前(P<0.05)。治疗后,试验组胃动素和生长抑素水平分别为(235.7±19.4),(18.8±2.5)pg·mL~(-1),显著低于对照组的(267.3±17.2),(20.3±1.4)pg·mL~(-1);胃泌素水平为(168.6±17.2)pg·mL~(-1),显著高于对照组的(142.8±11.4)pg·mL~(-1)(P<0.05)。2组治疗后胃动素、胃泌素和生长抑素水平与治疗前相比差异均有统计学意义(P<0.05)。2组治疗期间均无明显不良反应发生。结论健脾调中散对儿童功能性消化不良有较好的临床疗效且不良反应较少。
Objective To observe the clinical effect of Jianpi Tiaoshisan on functional dyspepsia children and its effect on improving gastrointestinal motility disorder. Methods 90 cases of children with functional dyspepsia were randomly divided into experimental group and control group, 45 cases each. The experimental group oral spleen Tiaoshisan, 5 to 9-year-old children each 10 m L; 10 to 14-year-old children each 20 m L, taken 1h after breakfast and dinner; domperidone oral domperidone suspension, 7 years old 5 m L; 8 to 10 years old 7.5 m L; 11 to 14 years old 10 m L. One month after treatment, the changes of major clinical symptoms, electrogastrogram, motilin, somatostatin and gastrin before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the experimental group was 86.67%, which was significantly higher than that of the control group (75.56%, P <0.05). After treatment, the clinical symptoms of the experimental group were significantly better than those of the control group (P <0.05). After treatment, the normal percentage of fasting gastric electrical rhythm was significantly higher than before treatment (P <0.05). After treatment, the levels of motilin and somatostatin in the test group were (235.7 ± 19.4) and (18.8 ± 2.5) pg · mL -1, respectively, which were significantly lower than those in the control group (267.3 ± 17.2 and 20.3 ± 1.4) pg · mL -1; the level of gastrin was (168.6 ± 17.2) pg · mL -1, which was significantly higher than that of the control group (142.8 ± 11.4 pg · mL -1) P <0.05). The levels of motilin, gastrin and somatostatin in the two groups after treatment were significantly different from those before treatment (P <0.05). No significant adverse reactions occurred in the two groups during the treatment. Conclusion Jianpi Tiaosan Powder has better clinical efficacy and less adverse reactions on functional dyspepsia in children.