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一例来自东非的22岁丹麦妇女,在1981年3月～7月内因出现疟疾症状曾分别服用氯喹基质1.2 g～1.5 g,共进行4次治疗。经血检确诊为恶性疟感染。在第4次治疗开始后,以患者血液加酸性枸橼酸盐葡萄糖(ACD)进行体外研究;并每天制作血片及收集血清和尿液测定氯喹含量。整个试验期间均能查见疟原虫。患者最后用1.5g甲氟喹治愈。体外研究是用Whatman CF 11赛珞璐柱除去ACD血样中的白细胞,获得恶性疟
An example is a 22-year-old Danish woman from East Africa who took chloroquine matrix 1.2 g to 1.5 g for malaria symptoms during March-July 1981 for a total of 4 treatments. Blood tests confirmed the falciparum malaria infection. In the first treatment after the start of the patient’s blood acid citrate dextrose (ACD) in vitro studies; daily production of blood films and serum and urine collection determination of chloroquine content. Plasmodium can be detected throughout the trial. The patient was finally cured with 1.5 g of mefloquine. In vitro studies were performed on Whatman CF 11 cellophane to remove leukocytes from ACD blood samples and obtain falciparum malaria