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作者对糖尿病药物 N~1-(4甲基—苯磺酰基)-N~2正丁脲的合成方法进行了比较,根据原料来源及劳动保护等条件,认为用对甲苯磺酰氨基甲酸甲酯与正丁胺缩合的方法最适宜于进行 N~1-(4甲基—苯磺酰基)-N~2正丁脲的工业生产,但有下列缺点:
The author compared the synthesis method of diabetic N ~ 1- (4-methyl-benzenesulfonyl) -N ~ 2 n-buthylurea. According to the sources of raw materials and labor protection, The method of condensation with n-butylamine is most suitable for commercial production of N-1- (4-methyl-benzenesulfonyl) -N ~ 2 n-buthylurea but has the following disadvantages: