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目的:探讨米非司酮配伍米索前列醇在稽留流产清宫术前的临床应用效果。方法:回顾性分析52例米非司酮配伍米索前列醇加清宫治疗稽留流产(A组)的临床效果,并与32例苯甲酸雌二醇加清宫治疗稽留流产者(B组)进行疗效比较。结果:A组服药后6 h内胚胎排出27例(51.92%),宫颈软化扩张率为100%,手术时间为5.2±1.5 min,术中出血量为19.3±8.5 ml,术后出血时间为4.2±1.3 d,均1次清宫成功,疼痛程度轻,均未发生人工流产综合征(0%);B组服药后6 h内均未见胚胎排出(0%),宫颈软化扩张者占6.25%,清宫前需扩宫,手术时间为11.2±3.5 mim,术中出血量为60.0±10.6 ml,术后出血时间为10.1±2.3 d,26例(81.25%)1次清宫成功,疼痛程度明显及人工流产综合征发生率高(13.46%);各项观察指标与A组相比,均有显著统计学差异(P<0.01)。结论:米非司酮配伍米索前列醇在稽留流产清宫术前应用是一种简便、安全、有效的方法,值得推广。
Objective: To investigate the clinical effect of mifepristone combined with misoprostol in the treatment of missed abortion. Methods: A retrospective analysis of 52 cases of mifepristone with misoprostol plus curettage abortion (A group) clinical efficacy, and 32 patients with estrogen benzoate benzoic acid treatment of abortion (B group) for treatment Compare Results: In the group A, 27 cases (51.92%) of embryos were discharged within 6 hours after treatment, the rate of cervical softening expansion was 100%, the operation time was 5.2 ± 1.5 minutes, the amount of blood loss was 19.3 ± 8.5 ml and the time of postoperative bleeding was 4.2 ± 1.3 days. All patients were successful in one-step curettage and the degree of pain was mild. No abortion syndrome occurred (0%). No embryo excretion (0%) was found within 6 hours after treatment in group B, and 6.25% , Before the Qing Palace need to dilatation, operation time was 11.2 ± 3.5 mim, intraoperative bleeding was 60.0 ± 10.6 ml, postoperative bleeding time was 10.1 ± 2.3 d, 26 cases (81.25%) 1 success of the Qing, the pain was significantly The incidence of induced abortion syndrome was high (13.46%). There were significant differences between the observation indexes and the A group (P <0.01). Conclusion: The combination of mifepristone and misoprostol is a simple, safe and effective method for the treatment of missed abortion. It is worth to be popularized.