论文部分内容阅读
背景:研究表明一氧化氮可能参与了脑卒中的病理过程,但其作用的研究结果具有争议性。目的:观察脑卒中患者血浆一氧化氮含量的变化情况,探讨一氧化氮在脑卒中发生发展过程中的作用和意义。设计:病例-对照研究。单位:一所市级医院的神经内科,血液科,检验科。对象:选择确诊为脑卒中的患者为研究对象,其中脑梗死47例,脑出血42例,正常对照组41例,均为健康体检者和献血者。方法:采用硝酸还原酶法分别测定研究对象入院时、发病后的第3,7,21天的一氧化氮含量,并与健康体检者进行对照。主要观察指标:各组患者血浆一氧化氮含量。结果:脑梗死组入院时、发病后的第3,7天的血浆一氧化氮含量比正常对照一氧化氮含量低,差异有显著性(P<0.01);第21天的血浆一氧化氮含量比入院时高(P<0.01),且与正常对照组比较差异无显著性意义(P>0.05)。脑出血组入院时、发病后的第3,7,21天的一氧化氮含量分别为(60.70±21.56)μmol/L,(55.19±28.53)μmol/L,(58.51±28.53)μmol/L,(62.13±23.30)μmol/L,比正常对照组低(t=4.3868,t=4.7476,t=4.1873,t=3.9698,P<0.01),且连续4次检验的血浆一氧化氮含量没有明显变化,差异无显著性意义(P>0.05)。脑梗死组前3次的血浆一氧化氮含量与脑出血同期的血浆一氧化氮含量比较差异无显著性意义(P>0.
Background: Studies have shown that nitric oxide may be involved in the pathological process of stroke, but the results of this study are controversial. Objective: To observe the changes of plasma nitric oxide in patients with stroke and to explore the role and significance of nitric oxide in the development of stroke. Design: Case-control study. Unit: a municipal hospital neurology, hematology, laboratory. PARTICIPANTS: A total of 47 patients with cerebral infarction, 42 with intracerebral hemorrhage and 41 with normal controls were selected as subjects for the diagnosis of stroke. All were healthy and blood donors. Methods: Nitric acid reductase method was used to determine the levels of nitric oxide on the 3rd, 7th and 21st days after admission to hospital, respectively, and compared with healthy subjects. MAIN OUTCOME MEASURES: Plasma nitric oxide content in each group. Results: At the admission of the cerebral infarction group, the plasma nitric oxide content was lower on the 3rd and 7th days after onset than that of the normal control group (P <0.01); on the 21st day, the plasma nitric oxide (P <0.01), and there was no significant difference with the normal control group (P> 0.05). The levels of nitric oxide on the 3rd, 7th and 21st days after onset of cerebral hemorrhage were (60.70 ± 21.56) μmol / L, (55.19 ± 28.53) μmol / L, (58.51 ± 28.53) μmol / L, (62.13 ± 23.30) μmol / L, which was lower than the normal control group (t = 4.3868, t = 4.7476, t = 4.1873, t = 3.9698, P <0.01) , No significant difference (P> 0.05). There was no significant difference in plasma nitric oxide level between the first three episodes of cerebral infarction group and the same period of cerebral hemorrhage (P> 0.