Angew.Chem.Int.Ed.2014,53,9539~9543Gracilamine是2005年由土耳其学者ünver等从纤细雪花莲(Galanthus gracilis)中分离得到的一种石蒜科类生物碱.Gracilamine与传统石蒜科类生物碱相比其结构更为复杂,具有五环体系和7个连续手性中心,其中包括1个全碳季碳和1个杂季碳.由于自然含量较少所以其生物活性尚未报道.最近,华东师范大学化学系高栓虎课题组报道了Gracilamine的全合成工作.该小组在对光促进的Nazarov环化进行系统研究的基础上,成功地应用该策略完成了 Angew.Chem.Int.Ed.2014,53,9539 ~ 9543Gracilamine is an Amaryllidaceae alkaloids isolated from Galanthus gracilis by the Turkish scholar ünver in 2005. Gracilamine and traditional Amaryllidaceae Alkaloids are more complex than their structures and have a pentacyclic system and seven consecutive chiral centers, including one all-carbon quaternary carbon and one quaternary carbon, and its biological activity has not been reported due to its low natural content. Recently, the team of Huanshinhu, Department of Chemistry, East China Normal University, reported the full synthesis of Gracilamine, and based on a systematic study of light-facilitated Nazarov cyclization, the team successfully applied this strategy