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目的:探讨寒冷季节正常妊娠和子痫前期孕妇循环肾素(PRA)和血管紧张素Ⅱ(AngⅡ)的水平的变化。方法:采用放射免疫分析方法检测孕妇血浆PRA和AngⅡ的水平。结果:与同季节型正常妊娠相比,冬季及过渡季型子痫前期组血浆PRA水平降低,过渡季型子痫前期组血浆AngⅡ水平降低,冬季型子痫前期组血浆AngⅡ水平升高(P均<0.05);与过渡季型正常妊娠相比,冬季型正常妊娠AngⅡ水平升高(P<0.05);与过渡季型子痫前期组相比,冬季型子痫前期组血浆AngⅡ水平升高(P<0.01);各组血浆PRA水平均无统计学差异(P>0.05)。结论:寒冷刺激时,子痫前期患者循环肾素-血管紧张素系统(RAS)显著激活,血浆AngⅡ升高,导致血管收缩增强,血管痉挛、组织缺血,可能是寒冷季节子痫前期发病率增高的原因之一。
Objective: To investigate the changes of circulating renin (PRA) and angiotensin Ⅱ (Ang Ⅱ) in normal pregnancy and preeclampsia in cold season. Methods: Radioimmunoassay was used to detect plasma levels of PRA and AngⅡ in pregnant women. Results: Compared with normal pregnant women in the same season, plasma PRA level decreased in the pre-eclampsia group and in the transitional pre-eclampsia group, and decreased in the pre-eclampsia group (P (P <0.05). Compared with the transitional normal pregnant women, the levels of AngⅡ in normal pregnancy were significantly increased (P <0.05). Compared with the transitional preeclampsia group, the plasma levels of AngⅡ in winter preeclampsia group were significantly increased (P <0.01). There was no significant difference in plasma PRA levels among all groups (P> 0.05). CONCLUSIONS: In cold stimulation, circulating renin-angiotensin system (RAS) is significantly activated in preeclampsia and plasma AngⅡ is increased, leading to increased vasoconstriction, vasospasm and tissue ischemia, which may be the incidence of preeclampsia in cold season One of the reasons for the increase.