论文部分内容阅读
已知Pfs25表达于刚形成的配子的表面,并持续存在于合子和动合子期,其与抵御蚊中肠的消化,动合子的运动,穿透围食膜及识别中肠表皮细胞受体等功能有关。由于Pfs25特异性单抗系传播阻断性抗体,因此该蛋白被认为是传播阻断疫苗的主要候选抗原。本文目的在于探讨Pfs25是否存在于卵囊期,如果存在,其特异性抗体是否影响卵囊的发育。3～5日龄斯氏按蚊或冈比亚按蚊感染恶性疟原虫配子体(NF54)后,于第3,6,8天
It is known that Pfs25 is expressed on the surface of freshly formed gametes and persists in zygotes and zygotes, which are resistant to digestion in mosquito midgut, movement of zygotes, penetration of perineal membranes, and recognition of midgut epithelial cell receptors Function related. Since Pfs25-specific mAbs transmit blocking antibodies, the protein is considered to be the major candidate antigen for the transmission of the blockade vaccine. The purpose of this article is to investigate whether Pfs25 is present in the oocyst stage and, if present, whether its specific antibody affects oocyst development. After 3 to 5 days of Anopheles stephena or Anopheles gambiae infected with Plasmodium falciparum gametophyte (NF54), on days 3, 6 and 8