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研究了稀水合肼的苄基化反应。发现了,用过量并能反复利用的稀水合肼进行该反应时,在低温的条件下,作为极易发生的特征反应为多苄基化,且主要生成物N,N’—二苄基肼。当苄基化温度为90°—95°时,则主要发生-苄基化反应,采用30%的水合肼进行苄基化时,苄肼之收率为51%;采用40%的水合肼时,苄肼之收率为62％;而当采用50％的水合肼时,在我们控制的特定条件下,几乎可以完全避免多苄基化的反应,一元取代物,即苄肼为主要产品,其收率可高达86%。鉴于稀水合肼的易于荻得和价格较低,因而由研究苄基化反应所得到的高产率的合成苄肼的上述方法,将适合苄肼,这一重要的中间化学药品的大量备制或工业生产。
Benzylation of hydrazine hydrate was studied. It has been found that when the reaction is carried out with an excess of hydrazine hydrate which can be reused, the characteristic reaction which is extremely prone to occur is polybenzylation at a low temperature and the major product, N, N’-dibenzylhydrazine . When the benzylation temperature is 90 ° -95 °, the main -benzylation occurs, the yield of benzylazine is 51% when benzylated by 30% hydrazine hydrate, and the yield is 40% by hydrazine hydrate , The yield of benzylhydrazine is 62%; and when 50% hydrazine hydrate is used, the polybenzylation reaction can be almost completely avoided under the specific conditions under our control. The monobasic substituent, benzylazine as the main product, The yield can be as high as 86%. In view of the fact that hydrazine hydrate is readily available and inexpensive, the above process for producing benzybenzylhydrazine in high yield from the study of benzylation will be suitable for the preparation of benzylazide, a large amount of this important intermediate chemical or Industrial production.