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目的:观察蜂蜡素(Fenglasu,FLS)及蜂蜡素固体分散体(Fenglasu solid dispersion,FLS-SD)对高脂血症大鼠脂代谢的影响。方法:高脂饲料喂养制备高脂血症大鼠模型,分别给予高,中,低剂量FLS及FLS-SD(50,100,200 mg·kg-1·d-1),测定大鼠血清中胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、载脂蛋白A1(apoA1)、载脂蛋白B100(apoB100)含量,计算LDL-C/HDL-C和apoA1/apoB100的比值。结果:FLS及FLS-SD均呈剂量和时间依赖性显著降低高血脂大鼠血清TC,TG,LDL-C,apoB100和LDL-C/HDL-C比值,显著升高HDL-C、apoA1和apoA1/apoB100比值,且FLS-SD作用强于FLS。结论:FLS-SD可有效调节高脂血症大鼠的脂代谢紊乱。
Objective: To observe the effects of Fenglasu (FLS) and Fengsu solid dispersion (FLS-SD) on lipid metabolism in hyperlipidemic rats. Methods: Hyperlipidemia rats were fed with high-fat diet and FLS-SD (50, 100, 200 mg · kg-1 · d-1) TG, LDL-C, HDL-C, apoA1 and apoB100 were calculated to calculate the level of LDL-C / HDL-C and apoA1 / apoB100 ratio. RESULTS: Both FLS and FLS-SD significantly reduced the serum levels of TC, TG, LDL-C, apoB100 and LDL-C / HDL-C in hyperlipidemic rats and increased the expressions of HDL-C, apoA1 and apoA1 / apoB100 ratio, and FLS-SD stronger than FLS. Conclusion: FLS-SD can effectively regulate lipid metabolism in hyperlipidemic rats.