论文部分内容阅读
目的:观察三维适形放射联合羟基喜树碱治疗原发性单结节型肝癌近期疗效及耐受性。方法:19例肝癌均采用三维适形放疗,≥90%的等剂量线包绕PTV,5￣8GY/次,1次/日,3次/周,总剂量55￣64GY/3￣4周;放疗开始同时给予羟基喜树碱5mg静脉滴注,连用21天,休息两周后改为羟基喜树碱10mg/d,连用5天,21天为1个周期,共3￣4周期。结果:19例患者均顺利完成治疗计划,完全缓解2例,部分缓解15例,总有效率89.5%(17/19);主要不良反应为骨髓抑制,均能耐受。结论:三维适形放疗加羟基喜树碱治疗原发性单结节型肝癌近期疗效好,局部控制率高,不良反应低,患者耐受性好。
Objective: To observe the short-term curative effect and tolerance of three-dimensional conformal radiotherapy combined with hydroxy camptothecin in the treatment of primary single nodular hepatocellular carcinoma. Methods: Nineteen cases of hepatocellular carcinoma were treated with three-dimensional conformal radiotherapy. The isodose lines ≥90% were wrapped around PTV, 5 ~ 8 Gy / time, once / day, 3 times / week and total dose 55 ~ 64GY / 3-4 weeks. Radiation therapy at the same time given hydroxy camptothecin 5mg intravenous infusion, once every 21 days, rest two weeks later changed to hydroxy camptothecin 10mg / d, once every 5 days, 21 days for a period of 3 to 4 cycles. Results: All the 19 patients completed the treatment plan successfully. Two cases were completely relieved and 15 cases partially relieved. The total effective rate was 89.5% (17/19). The main adverse reaction was myelosuppression, which could be tolerated. Conclusion: Three-dimensional conformal radiotherapy plus hydroxy camptothecin in the treatment of primary single nodular hepatocellular carcinoma has good short-term curative effect, high local control rate, low adverse reactions and good patient tolerance.