论文部分内容阅读
目的探讨自身免疫型肝炎(autoimmune hepatitis,AIH)患者的临床特点及泼尼松加环磷酰胺治疗的效果。方法 检测AIH组(16例)、其他慢性肝炎组(54例)、抗核抗体(ANA)阳性对照组(68例)和ANA阴性对照组(101例)血清中ANA、甘油三酯(TG)、胆固醇(TCHOL)、高/低密度脂蛋白(HDL/LDL)、总蛋白(TP)、球蛋白(GLB)、白蛋白(ALB)、乙型肝炎五项指标、丙型肝炎抗体、狼疮六项指标,并对16例AIH患者使用泼尼松加环磷酰胺的治疗效果进行跟踪,检测其TP、ALB、GLB、TG、TCHOL、谷丙转氨酶(ALT)、谷草转氨酶(AST)、胆碱酯酶(CHE)和前白蛋白(PA)的变化。结果四组人群血清TP、ALB、GLB、TCHOL、HDL和LDL水平差异有统计学意义,治疗前后的AIH患者血清各指标水平差异有统计学意义。结论 AIH患者有其显著的临床诊断特点,可与其他慢性肝炎患者相鉴别,采用泼尼松加环磷酰胺的治疗有效。
Objective To investigate the clinical characteristics of patients with autoimmune hepatitis (AIH) and the effect of prednisone and cyclophosphamide. Methods The levels of ANA, triglyceride (TG) in serum of AIH group (54 cases), ANA positive control group (68 cases) and ANA negative control group (101 cases) TCHOL, HDL / LDL, TP, GLB, ALB, hepatitis B, hepatitis C, lupus The indexes of 16 patients with AIH were followed up for treatment of prednisone plus cyclophosphamide. The levels of TP, ALB, GLB, TG, TCHOL, ALT, AST, Esterase (CHE) and prealbumin (PA) changes. Results The serum levels of TP, ALB, GLB, TCHOL, HDL and LDL in the four groups of patients were significantly different. The serum levels of AIH before and after treatment had statistical significance. Conclusions The AIH patients have significant clinical diagnostic features, which can be differentiated from other patients with chronic hepatitis. The treatment with prednisone plus cyclophosphamide is effective.