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肿瘤从分子病理角度来看是一类基因突变所致的疾病,更常见是由多种基因综合变化所致,包括细胞原癌基因的活化,抑癌基因的失活以及遗传不稳定状态等,并可涉及不同染色体上多部位基因的改变,因此揭示了细胞恶性转化序列的演变及演变过程的分子基础,不仅可进一步探讨癌变的机制,也可利用这些基因变化进行诊断、治疗和判断肿瘤的预后.随着原癌基因、抑癌基因和转移相关基因的研究向纵深化发展,人们认识到:(1)多种癌基因协作参与人体肿瘤的发生;(2)抑癌基因的失活是人体肿瘤发生的重要条件;(3)基因的累积性突变最终导致肿瘤的发生,突变顺序占重要地位,但更重要的是突变的累积.(4)基因遗传稳定性受损,DNA修复系统起关键作用.胃癌涉及许多基因改变,包括多种原癌基因、抑癌基因、转移相关基因,细胞周期调节因子和DNA修复基因等,现就近期胃癌基因研究进展作一综述.
The tumor is a disease caused by a series of gene mutations from the perspective of molecular pathology, and is more commonly caused by comprehensive changes in various genes, including activation of cellular proto-oncogenes, inactivation of tumor suppressor genes, and genetic instability. It may involve the alteration of genes at multiple sites on different chromosomes, thus revealing the molecular basis for the evolution and evolution of malignant transformation sequences of cells. It can not only further explore the mechanism of canceration, but also make use of these genetic changes to diagnose, treat, and judge tumors. With the development of proto-oncogenes, tumor suppressor genes, and metastasis-related genes, we have realized that: (1) Many oncogenes cooperate to participate in the occurrence of human tumors; (2) Inactivation of tumor suppressor genes is (3) Accumulation of mutations in genes eventually leads to the occurrence of tumors. The mutation sequence occupies an important position, but more importantly, the accumulation of mutations. (4) The genetic stability of genes is impaired, and the DNA repair system plays an important role. The key role. Gastric cancer involves many genetic changes, including a variety of proto-oncogenes, tumor suppressor genes, metastasis-related genes, cell cycle regulators and DNA repair genes, etc. Because Progress reviewed.