本文对感染华支睾吸虫豚鼠的胆管病变超微结构进行了观察。结果表明,随着感染时间(1～9周)的推移,病变逐渐加重。胆管上皮微绒毛肿胀、脱落;胞质、核质均减少;细胞邻界变直,连结部分离,并有纤维组织向内增生;细胞器改变明显。胆管上皮形成假复层,胆管壁周围结缔组织明显增生。 In this paper, ultrastructural changes of biliary tract in guinea pigs infected with Clonorchis sinensis were observed. The results showed that, with the passage of infection time (1 to 9 weeks), the lesions gradually increased. Bile duct epithelial microvilli swollen, fall off; cytoplasm, nuclear mass decreased; cell neighbors straightened, the connection part of the separation, and fibrous tissue inwards proliferation; organelles changed significantly. Bile duct epithelium formation of pseudostratified, connective tissue around the bile duct wall hyperplasia.