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目的观察腹腔注射七氟烷(sevoflurance,Sev)对小鼠镇痛及催眠作用的影响。方法小鼠腹腔注射七氟烷后用热板和扭体实验、催眠实验分别观察小鼠热板痛阈值(HPPT)、扭体次数(WT)和睡眠时间(ST)的变化。结果腹腔注射七氟烷能增大HPPT(P<0.05,P<0.01),减少WT(P<0.01),延长ST(P<0.01)。结论在本实验条件下,小鼠腹腔注射七氟烷可产生催眠和镇痛作用。
Objective To observe the effects of intraperitoneal injection of sevoflurance (Sev) on the analgesic and hypnotic effects in mice. Methods After intraperitoneal injection of sevoflurane, mice were treated with hot plate and writhing. The changes of hypothermia threshold (HPPT), writhing times (WT) and sleep time (ST) in mice were observed by hypnosis test. Results Intraperitoneal injection of sevoflurane increased HPPT (P <0.05, P <0.01), decreased WT (P <0.01) and prolonged ST (P <0.01). Conclusion Under the experimental conditions, intraperitoneal injection of sevoflurane in mice can produce hypnotic and analgesic effects.