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目的:检测可溶性上皮性钙粘附素(sECD)在膀胱移行细胞癌患者尿中的含量及其临床意义。方法:用ELISA方法测定31例膀胱移行细胞癌患者、17例泌尿系良性病变患者及11例正常人尿中sECD的水平,对比各组间指标并结合肿瘤生物学性质进行相关性分析。结果:膀胱移行细胞癌患者尿中sECD水平高于正常人和泌尿系良性病变患者;尿中sECD水平与膀胱移行细胞癌的分期分级呈正相关,与肿瘤大小及个数无关;复发患者尿中sECD水平高于初发患者。结论:膀胱移行细胞癌患者尿中sECD水平升高,与膀胱肿瘤的生物学性质有密切关系,对于早期诊断膀胱移行细胞癌以及估计肿瘤的生物学性质具有重要价值。
Objective: To detect the content of soluble epithelial cadherin (sECD) in urinary bladder transitional cell carcinoma and its clinical significance. Methods: The urinary levels of sECD were measured in 31 cases of transitional cell carcinoma of the bladder, 17 cases of urinary tract benign disease and 11 cases of normal urine by ELISA. The correlation between each group and the biological characteristics of the tumor was analyzed. Results: The urinary levels of sECD in bladder transitional cell carcinoma were significantly higher than those in normal and urologic benign lesions. The urinary sECD level was positively correlated with the stage of bladder transitional cell carcinoma, but not with the tumor size and number. The urinary sECD The level is higher than the initial patients. CONCLUSIONS: The elevated urinary levels of sECD in bladder transitional cell carcinoma patients are closely related to the biological properties of bladder tumors, which is of great value in the early diagnosis of bladder transitional cell carcinoma and in the estimation of tumor biological properties.