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目的 探讨母体和脐血血清胰岛素样生长因子 1(IGF 1)、C肽 (CP)及胰岛素样生长因子结合蛋白 1(IGFBP 1)质量浓度对新生儿出生体重的影响。方法 选择 12例大于胎龄儿 (LGA)、15例适于胎龄儿 (AGA)和 2 0例小于胎龄儿 (SGA) ,分为 3组 ,分别抽取脐血和其母外周静脉血 ,分离血清。采用ELISA法测定IGF 1、CP和IGFBP 1。结果 (1)LGA组脐血IGF 1、CP、IGFBP 1质量浓度 (ng·mL-1)分别为 5 9 76± 14 5 0 ,1 36± 0 5 8,5 3 78±19 6 7;AGA组为 33 6 5± 12 74 ,0 90± 0 4 5 ,10 4 79± 2 7 6 0 ;SGA组为 17 0 5± 8 10 ,0 5 2± 0 2 2 ,16 9 2 1± 5 5 30 ;3组间差异有显著性意义 (P <0 0 1)。 (2 )LGA组新生儿母亲血清IGF 1、CP、IGFBP 1质量浓度 (ng·mL-1)分别为2 6 7 15± 99 4 3,2 84± 0 93,15 8 5 0± 5 1 2 5 ;AGA组母亲分别为 2 37 34± 10 5 5 6 ,2 71± 0 72 ,170 78± 6 3 6 9;SGA组分别为 2 2 9 5 3± 94 17,2 5 9± 0 83,188 90± 74 0 4 ;3组间比较差异均无显著性。但同组患儿母血IGF 1、CP及IGFBP 1均显著高于脐血水平 (除SGA组母血与脐血IGFBP 1差异无显著性外 )。 (3)新生儿出生体重与脐血IGF 1、CP呈正相关 (r分别为 0 814、0 6 5 4 ,P <0 0 1) ;与IGFBP 1?
Objective To investigate the effects of serum concentrations of insulin like growth factor 1 (IGF 1), c-peptide (CP) and insulin-like growth factor binding protein 1 (IGFBP 1) on birth weight in neonates. Methods Twelve cases of LGA, 15 cases of gestational age (AGA) and 20 cases of small gestational age (SGA) were selected and divided into three groups. Umbilical cord blood and their peripheral venous blood were collected respectively. Separation of serum. IGF 1, CP and IGFBP 1 were measured by ELISA. Results (1) The levels of IGF-1, CP and IGFBP-1 in cord blood of LGA group were respectively 5 9 76 ± 14 5 0, 1 36 ± 0 58 and 53 78 ± 19 6 7; AGA Group was 33 6 5 ± 12 74, 0 90 ± 0 4 5, 10 4 79 ± 2 7 6 0; SGA group was 17 0 5 ± 8 10, 0 5 2 ± 0 2 2, 16 9 2 1 ± 5 5 30; There was a significant difference between the three groups (P <0.01). (2) The serum concentrations of IGF1, CP and IGFBP1 in neonatal mothers in LGA group were 267 15 ± 99 4 3,2 84 ± 0 93,15 8 5 0 ± 5 1 2 5; the AGA group’s mothers were respectively 2 37 34 ± 10 5 5 6, 2 71 ± 0 72 and 170 78 ± 6 3 6 9; in the SGA group they were 2 2 9 5 3 ± 94 17,2 5 9 ± 0 83,188 90 ± 74 0 4; no significant difference between the three groups. However, the levels of maternal serum IGF1, CP and IGFBP1 were significantly higher than those of umbilical cord blood in the same group (except for the difference between the SGA group and the umbilical cord blood IGFBP1 group). (3) Neonatal birth weight was positively correlated with IGF 1, CP in umbilical cord blood (r = 0 814, 6 5 4, P <0.01)