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本文通过检测大鼠支气管肺泡灌洗液中LDH总活性及LDH同功酶改变,从时间和剂量两个方面对吸入氰戊菊酯的毒性作用作了探讨。结果表明:染毒后1天支气管肺泡灌洗液中LDH,LDH_5含量均升高,第14天恢复正常,酶谱改变较LDH总活性变化敏感。
In this paper, by detecting the total activity of LDH and LDH isozymes in the bronchoalveolar lavage fluid of rats, the toxic effects of inhalation of fenvalerate in both time and dose were discussed. The results showed that the levels of LDH and LDH_5 in bronchoalveolar lavage fluid increased on the 1st day after exposure and returned to normal on the 14th day. The change of zymogram was more sensitive than the change of the total LDH activity.