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[目的]探讨尿毒症伴神经功能损害患者的血清烯醇化酶(NES)和钠钾ATP酶活性的变化。[方法]选取某院2009年6月～2010年12月收治的40例尿毒症伴神经功能损害患者为研究对象(观察组),该组患者入院后均采用对症药物治疗,另选取健康体检者40例(对照组),测定观察组治疗前后及对照组的血尿素氮(BUN)、血清肌酐(SCr)、β2-微球蛋白(β2-MG)、血清烯醇化酶(NES)和钠钾ATP酶的活性水平,并进行比较。[结果]观察组患者治疗前各项指标与正常组之间差异有统计学意义,P﹤0.05,且脑电图均呈异常状态;观察组治疗后BUN、SCr、β2-MG均较治疗前显著下降,P﹤0.05,血清NES显著降低,钠钾ATP酶显著升高,P﹤0.05。且有42.5%(17/40)的患者脑电图正常。[结论]NES可作为尿毒症神经功能损害反应的诊断指标,其灵敏性优于脑电图检查,药物治疗在一定程度上可降低患者的神经损害和减少红细胞破坏。
[Objective] To investigate the changes of serum enolase (NES) and sodium-potassium ATPase activity in patients with uremia and neurological impairment. [Methods] Forty patients with uremic neurological deficits admitted in a hospital from June 2009 to December 2010 were selected as the study group (observation group). All patients in the hospital were treated with symptomatic drugs after admission. (BUN), serum creatinine (SCr), β2-microglobulin (β2-MG), serum enolase (NES) and sodium and potassium in the observation group before and after treatment were measured in 40 cases (control group) ATPase activity levels, and compared. [Results] The differences between the observation group before treatment and the normal group were statistically significant, P <0.05, and the EEG were abnormal state; the observation group after treatment BUN, SCr, β2-MG than before treatment P <0.05, serum NES decreased significantly, Na + -K + ATPase increased significantly, P <0.05. And 42.5% (17/40) of patients with normal EEG. [Conclusion] NES can be used as a diagnostic indicator of neurological dysfunction in uremia and its sensitivity is better than that of electroencephalogram (EEG). The drug treatment can reduce the nerve damage and reduce the destruction of erythrocytes to a certain extent.