近年来,双吡啶衍生物作为新一代肌力扩张药(inodilator)用于心衰的静脉治疗。其中之一是甲腈利酮(milrinone),它改善肌力状态和减低心室后负荷,导致血流动力学改善。由于收缩期和舒张期功能有着密切联系,可以预料,舒张期心肌性质受收缩功能改变的影响,甲腈利酮疗法也如此。由于单独心室容量改变的结果,舒张终末压可以偏移,在能作出舒张功能改变的肯定结论前,必须测量左室舒张压力容量(LVDPV)关系。以后则应证实有关变数能改变,这个关系而不影响内源性舒张期心肌性质。这些变数可分为静态影响(冠脉血管床容量、右室压和心包压)和动力性影响(粘弹性和心肌主动松弛)。已知灌注血流(血管床容量)的冠脉灌注压增加能使室壁变硬。右室压或心包压改变通过跨室壁压力改变是 In recent years, bipyridine derivatives have been used as a new generation of inodilators for the treatment of venous failure of heart failure. One of them is milrinone, which improves muscle strength and reduces ventricular afterload, resulting in improved hemodynamics. Due to the close relationship between systolic and diastolic functions, it is expected that diastolic myocardial properties will be affected by changes in contractile function, as well as with nitrile therapy. Due to changes in individual ventricular volume, end-diastolic pressure may shift, and left ventricular diastolic pressure capacity (LVDPV) must be measured before a positive conclusion can be made of changes in diastolic function. Later, it should be confirmed that the variables can change, this relationship without affecting endogenous diastolic myocardial properties. These variables can be divided into static effects (coronary vascular bed volume, right ventricular pressure and pericardial pressure) and dynamic effects (viscoelasticity and active relaxation of the myocardium). It is known that increased coronary perfusion pressure perfusing the bloodstream (vascular bed volume) hardens the walls of the chamber. Right ventricular pressure or pericardial pressure changes through the transmural pressure change is