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目的探讨环氧合酶2(COX2)、血管内皮生长因子C(VEGFC)在宫颈癌及正常宫颈组织的表达情况及其与宫颈癌生物学行为之间的关系。方法采用免疫组化SP法检测郑州大学第一附属医院2000年1月至2003年3月期间76例宫颈癌和19例正常宫颈组织中COX2、VEGFC的表达。结果COX2和VEGFC蛋白在宫颈癌和正常宫颈组织中的表达差异有显著性意义(P<001);COX2表达与宫颈癌淋巴结转移、组织学分级和组织学类型显著相关,VEGFC的表达与淋巴结转移、组织学分级和临床分期显著相关。COX2与VEGFC的表达之间呈正相关(r=0553,P<001)。结论COX2和VEGFC2种蛋白表达与宫颈癌的发生发展相关,并对宫颈癌的淋巴结转移可能起重要作用。
Objective To investigate the expression of cyclooxygenase 2 (COX2) and vascular endothelial growth factor C (VEGFC) in cervical cancer and normal cervical tissues and their relationship with the biological behavior of cervical cancer. Methods Immunohistochemical SP method was used to detect the expression of COX2 and VEGFC in 76 cases of cervical cancer and 19 cases of normal cervical tissue from January 2000 to March 2003 in the First Affiliated Hospital of Zhengzhou University. Results The expression of COX2 and VEGFC protein in cervical cancer and normal cervical tissue were significantly different (P <001). The expression of COX2 was significantly correlated with lymph node metastasis, histological grade and histological type in cervical cancer. The expression of VEGFC was correlated with lymph node metastasis , Histological grade and clinical stage were significantly correlated. There was a positive correlation between the expression of COX2 and VEGFC (r = 0553, P <001). Conclusion The expression of COX2 and VEGFC2 proteins may be related to the development of cervical cancer and may play an important role in the metastasis of cervical cancer.