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目的:观察荭叶心通软胶囊对家兔离体血管条的影响。方法:分离家兔胸主动脉降段,观察不同剂量荭叶心通软胶囊对离体血管平滑肌张力的影响。结果:荭叶心通软胶囊对高钾及高钙诱导的离体血管平滑肌的收缩具有舒张作用,而对去甲肾上腺素(NA)诱导的离体血管平滑肌收缩未见明显影响。结论:荭叶心通软胶囊可能影响电压门控钙通道而影响血管平滑肌的收缩。
Objective: To observe the effect of Qiyexintong soft capsule on isolated blood vessel strips in rabbits. Methods: The descending segments of rabbit thoracic aorta were isolated and the effects of different doses of Qiyexintong soft capsule on the tension of isolated vascular smooth muscle were observed. RESULTS: Qiyinxintong soft capsule had a relaxing effect on the contraction of isolated vascular smooth muscle induced by high potassium and calcium, but had no obvious effect on the contraction of isolated vascular smooth muscle induced by norepinephrine (NA). Conclusion: Qiyexintong soft capsule may affect voltage-gated calcium channels and affect the contraction of vascular smooth muscle.