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本研究的目的是评价RU486对子宫收缩力和子宫对前列腺素的敏感性,并且指出用RU486辅助前列腺素治疗可增加完全流产率。 10例志愿者要求中断早孕记录了子宫收缩力,5例病人服用RU486 25mg,每日2次,共4天,RU486治疗第4天早晨有子宫收缩并开始有少量出血,但未立即流产,余5例做为对照,记录前未行治疗。用一个压力转换器连接Grass多种波动描记器经颈管进入羊膜外达宫底部,记录自然子宫收缩图型至少30分钟,而后全部病人均注射一次前列腺素类似物PGE_20.25mg或间隔30分钟重复注射,剂量从0.05～0.25mg。5例用RU_(486)治疗者未用其它治疗而流产,5例对照者记录结束后用真空吸引中断。
The purpose of this study was to evaluate the RU486 sensitivity to uterine contractility and uterine prostaglandins and to point out that RU486-assisted prostaglandin therapy can increase the rate of complete abortion. Ten volunteers asked for uterine contractions recorded in the first trimester of pregnancy. Five patients took RU486 25 mg twice daily for 4 days. RU486 had uterine contractions on the morning of the fourth day and started to have a small amount of bleeding but did not immediately abort. 5 cases as a control, no treatment before recording. A pressure transducer connected to a variety of Grass multiple wave tracer through the neck tube into the bottom of the amniotic uterus to record the pattern of natural contraction of the uterus at least 30 minutes, and then all patients were injected with prostaglandin analogue PGE20.25mg or interval of 30 minutes repeat Injection, the dose from 0.05 ~ 0.25mg. Five patients treated with RU_ (486) were aborted without any other treatment, and five controls were interrupted by vacuum aspiration after recording.