骨肉瘤osteosarcoma是最常见的骨原发性恶性肿瘤,研究表明:肿瘤细胞的侵袭及血行转移是一个多步骤的、肿瘤细胞与机体细胞相互作用的生物学过程,与肿瘤治疗的远期效果密切相关。大致步骤是原发灶肿瘤细胞的增殖;肿瘤细胞自原发灶游离,侵袭穿过细胞外基质和血管基底膜、游走至血 Osteosarcoma Osteosarcoma is the most common primary bone malignancy. Studies have shown that tumor cell invasion and hematogenous metastasis are multi-step biological processes that interact with tumor cells and have a long-term effect on tumor treatment Related. The approximate steps are the proliferation of primary tumor cells; tumor cells free from the primary tumor, invasion through the extracellular matrix and vascular basement membrane, walked to the blood