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目的 :研究柴胡疏肝散对慢性束缚应激性肝郁证大鼠的影响。方法 :应用慢性束缚应激方法建立肝郁证动物模型 ,观察大鼠体重、1%蔗糖水摄取量 ,放射免疫法测定血浆促肾上腺皮质激素 (ACTH)水平。结果 :柴胡疏肝散能部分对抗应激导致的大鼠体重增长缓慢和高促ACTH ,能增加应激大鼠的蔗糖水摄取量。结论 :柴胡疏肝散可调节慢性束缚应激模型大鼠的功能紊乱。
Objective: To study the effect of Bupleurum Shugan Powder on chronic restraint stress liver-qi stagnation rats. METHODS: The animal model of liver depression was established by chronic restraint stress method. The body weight and 1% sucrose water intake of the rats were observed. Plasma adrenocorticotropic hormone (ACTH) levels were measured by radioimmunoassay. Results :Chaihu Shugan Powder can partially reduce the body weight gain and increase ACTH induced by stress, and increase the sucrose water intake of stress rats. Conclusion: Chaihu Shugan Powder can regulate the dysfunction of chronic restraint stress model rats.