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目的研究施他林联合可利新在处理食管胃底静脉曲张破裂引发重度上消化道出血时的疗效。方法74例肝硬化合并重度上消化道出血患者随机分为3组:施他林联合可利新组26例;单用施他林组24例;单用可利新组24例。结果三组病例总止血率分别为96.2%、72.7%和70.8%(P<0.05);平均出血时间分别为(8.66±4.92)h、(13.47±9.02)h和(13.58±8.35)h(P<0.05);输血量分别为(869.23±403.75)ml、(1172.72±513.79)ml和(1250.00±599.27)ml(P<0.05);总病死率分别为3.8%、27.3%和29.2%(P<0.05)。结论施他林联合可利新治疗肝硬化并发重度上消化道出血在近期止血率和总止血成功率方面明显优于单用施他林或可利新,具有止血迅速、疗效肯定、安全可靠等优点。
Objective To study the effect of combination of Sitarin with Coriolis on the treatment of severe upper gastrointestinal hemorrhage caused by rupture of esophageal and gastric varices. Methods A total of 74 patients with cirrhosis and severe upper gastrointestinal hemorrhage were randomly divided into three groups: Shitarin combined with Kelixin group (n = 26), monotherapy with sitarin (n = 24) and Coriolis group alone (n = 24). Results The total hemostasis rates of the three groups were 96.2%, 72.7% and 70.8%, respectively (P <0.05). The average bleeding time was (8.66 ± 4.92) h, (13.47 ± 9.02) h and (13.58 ± 8.35) h (P <0.05). The total mortality rates were (869.23 ± 403.75) ml, (1172.72 ± 513.79) ml and (1250.00 ± 599.27) ml respectively 0.05). Conclusion Sitarin combined with clonidine in the treatment of cirrhosis complicated by severe upper gastrointestinal bleeding in the recent hemostatic rate and total success rate of hemostasis was significantly better than single strytine or kelibin, with rapid hemostasis, efficacy, safety and reliability advantage.