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为了更准确全面地评估冠状动脉的动力学特性,采用血管内超声技术和血压测量设备获取冠状动脉内的超声图像、血流多普勒信号和血压曲线。使用动态轮廓模型从血管内的超声图像测量出管腔的截面积曲线,使用形态学和动态规划法提取多普勒信号中的流速信息,在心电同步下计算出血流量随心动周期的变化。结合血管内的血压曲线,通过傅里叶级数计算出冠状动脉等效阻抗。通过对人工控制下猪心肌微循环障碍实验的数据分析,观察到本方法估计出的血管阻抗可以反映冠状动脉的供血能力、扩张能力随微循环功能衰弱的变化。这一技术的实现,有望为医学临床提供一种新的辅助诊断参数。
In order to evaluate the dynamic characteristics of coronary arteries more accurately and comprehensively, intravascular ultrasound images, blood flow Doppler signals and blood pressure curves were obtained with intravascular ultrasound and blood pressure measurement equipment. The dynamic contour model was used to measure the cross-sectional area curve of the lumen from the intravascular ultrasound image. The morphological and dynamic programming method was used to extract the flow velocity information in the Doppler signal. The changes of the blood flow with the cardiac cycle were calculated under electrocardiogram synchronization. Combined with intravascular blood pressure curve, calculated by Fourier series equivalent coronary artery impedance. Through the data analysis of experimental control of myocardial microcirculation disturbance in pigs under artificial control, it is observed that the blood vessel impedance estimated by this method can reflect the change of coronary blood supply and expansion ability with the weakening of microcirculation. The realization of this technique is expected to provide a new diagnostic aid for clinical medicine.