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目的探讨Endoglin在卵巢上皮性肿瘤血管生成中的意义。方法采用免疫组织化学方法,对本院2000年12月至2003年12月手术切除的70例卵巢上皮肿瘤标本分别标记CD34和Endoglin,并分别进行微血管密度(microvessel density,MVD)计数。结果CD34标记的MVD在良性和恶性卵巢上皮性肿瘤间无统计学差异(P>0.05),而Endoglin标记的MVD在良性和恶性肿瘤间差异有统计学意义(P<0.05);恶性卵巢上皮性肿瘤临床Ⅰ～Ⅱ期CD34和Endoglin标记的MVD均高于Ⅲ～Ⅳ期;CD34标记的MVD在恶性卵巢上皮性肿瘤病理分级Ⅰ、Ⅱ、Ⅲ级间无统计学差异(P>0.05),而病理分级Ⅲ级Endoglin标记的MVD明显高于Ⅰ～Ⅱ级。结论Endoglin标记计数的MVD优于CD34、CD31和VonWille-brand因子等标记的MVD,可作为肿瘤血管生成状态的评价指标。
Objective To investigate the significance of Endoglin in angiogenesis of ovarian epithelial tumor. Methods 70 cases of ovarian epithelial tumor resected in our hospital from December 2000 to December 2003 were labeled with CD34 and Endoglin by immunohistochemical method respectively and counted for microvessel density (MVD). Results There was no significant difference in the MVD of CD34 between benign and malignant ovarian epithelial tumors (P> 0.05), while the MVD of Endoglin was significantly different between benign and malignant tumors (P <0.05). Malignant ovarian epitheliality The clinical stage I ~ II CD34 and Endoglin markers MVD were higher than the stage Ⅲ ~ Ⅳ; CD34-labeled MVD in malignant ovarian epithelial tumor pathological grade Ⅰ, Ⅱ, Ⅲ grade no significant difference (P> 0.05), and Pathological grade Ⅲ endoglin marked MVD was significantly higher than Ⅰ ~ Ⅱ grade. Conclusions MVD of Endoglin marker is better than that of MVD labeled with CD34, CD31 and Von Wille-brand, which can be used as an indicator of tumor angiogenesis.