前言早在1935年Hoskins和Magrassi就发现了病毒的干扰现象。当时,Hoskins将黄热病的嗜神经性毒株和嗜内脏性毒株分别或同时接种于恒河猴后,发现嗜神经毒株能保护猴子免受嗜内脏毒株的致死作用;Magrassi亦指出了感染家兔的疱疹病毒不同毒株之间存在着干扰现象。但是,促使这种现象发生的主要原因,直至1957年Issacs和Lindenman发现干扰素以后才为人们所了解。随着研究工作的深入,人们逐渐了解到,干扰素除具有抗病毒作用外,尚有多种 Preface As early as 1935, Hoskins and Magrassi discovered the virus interference. At the time, Hoskins, after separately or simultaneously inoculating yellowish fever neurotropic and gonadotropic strains in rhesus monkeys, found that the neurotropic strains protected the monkeys from the lethal effects of necrotrophs; Magrassi also pointed out There are interferences between different strains of herpes virus infected rabbits. However, the main reason for this phenomenon was not known until after Issacs and Lindenman discovered interferon in 1957. With the deepening of research work, people gradually understand that, in addition to interferon has antiviral effects, there are a variety of