肺表面活性物质(SAM)是维持肺泡稳定和正常通气的重要物质,其生理功能人们早已了解,但作为药物用于临床仅是近十几年的事。SAM 的主要成分是饱和卵磷脂,常用的SAM 制剂分为两大类,一类是自然 SAM,由牛肺(Surfactant TA,CLSE 及 Alveofact)、猪肺(Curosurf)或人羊水中提取,含有脱辅基蛋白。另一类是人工合成 SAM(ALEC 及 Exo-surf),不含蛋白质。实验及临床均已证实,自然 Pulmonary surfactant (SAM) is an important substance to maintain stable and normal alveolar, its physiological function has long been known, but as a drug for clinical use is only a matter of more than a decade. The main component of SAM is saturated lecithin. Commonly used SAM preparations fall into two major categories, one is natural SAM, extracted from bovine lung (Surfactant TA, CLSE and Alveofact), Curosurf or human amniotic fluid, Auxiliary protein. The other is the synthetic SAM (ALEC and Exo-surf), protein-free. Experimental and clinical have been confirmed, naturally