由于胰岛素注射给药不易为糖尿病人所接受,因此人们一直在寻找其它给药途径。胰岛素口服疗效差的主要原因是:(1)经胃肠道时蛋白质降解失活;(2)易自身结合形成高分子量的齐聚物(oligomers)。因此,被动扩散通过胃肠道膜的活性胰岛素不足以产生治疗效果。作者曾证明,以聚乙二醇鲸蜡醇醚1000为吸收促进剂,将胰岛素注入空肠能显著降 Because insulin injections are not readily accepted by people with diabetes, people are always looking for other routes of administration. The main reasons for the poor oral efficacy of insulin are: (1) Inactivation of protein degradation through the gastrointestinal tract; (2) Easily self-binding to form high molecular weight oligomers. Therefore, active insulin that passively diffuses through the membrane of the gastrointestinal tract is not sufficient to produce a therapeutic effect. The authors have shown that polyethylene glycol cetyl ether 1000 as an absorption accelerator, the injection of insulin into the jejunum can be significantly reduced