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目的:探讨心理干预在先兆流产治疗中的临床疗效及其对免疫机制的影响。方法:以先兆流产孕妇施行常规治疗+心理干预80例作为研究组,以先兆流产孕妇施行常规治疗80例作为对照组A,以同期无流产病史的早孕妇女80例作为对照组B。以SCL-90症状自评量表评估心理干预对先兆流产孕妇心理状况及疗效的影响,测定各组考的松(Cortisol)、IL-2、IL-10及TGF-β1水平,分析其对先兆流产患者内分泌的影响。结果:先兆流产组与无流产病史组相比,SCL-90评分、Cortisol及IL-2水平显著增高,IL-10和TGF-β1水平显著降低;心理干预组与常规治疗组相比,SCL-90评分、Cortisol及IL-2水平显著降低,IL-10和TGF-β1水平及妊娠成功率显著增高。结论:心理干预可能通过影响先兆流产患者免疫机制发挥治疗作用。
Objective: To investigate the clinical effect of psychological intervention in the treatment of threatened abortion and its effect on the immune mechanism. Methods: Eighty pregnant women undergoing threatened abortion were treated with conventional therapy and psychological intervention. 80 pregnant women undergoing threatened abortion were given routine treatment as control group A, and 80 pregnant women with no previous history of miscarriage as control group. The SCL-90 Symptom Checklist 90 was used to evaluate the effect of psychological intervention on the psychological status and therapeutic effect of threatened abortion. The levels of Cortisol, IL-2, IL-10 and TGF-β1 in each group were measured, Endocrine effects in abortion patients. Results: The levels of SCL-90, Cortisol and IL-2 in threatened abortion group were significantly higher than those in non-abortion history group, while the levels of IL-10 and TGF-β1 were significantly decreased. Compared with conventional treatment group, SCL- 90 scores, Cortisol and IL-2 levels were significantly lower, IL-10 and TGF-β1 levels and pregnancy success rate was significantly higher. Conclusion: Psychological intervention may play a therapeutic role through influencing the immune mechanism of threatened abortion patients.