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癌细胞表面不同于正常细胞的表面。癌细胞不象正常细胞那样彼此粘附得紧,因此当它们入侵组织时,它们的活动有如分开的实体(独立单位)。癌细胞遇刀豆球蛋白 A(ConA)时易凝集,而正常细胞不会这样。ConA 和相类似物质的作用已被作为一种方法用于鉴别正常和变形(或称肿瘤)细胞的表面。为着解释这些物质对细胞的凝集作用,许多生物学者已进行了研究和描述。现在国家癌研究所的 Mark Willingham 和 Ira pastan 得出一新的假设去直接确定 ConA 为什么和如何去凝集变形的而不是正常的细胞。这一假设引起调查者们极大的兴趣和争论。
The surface of cancer cells is different from the surface of normal cells. Cancer cells do not adhere to each other like normal cells, so when they invade tissue, they behave like separate entities (independent units). Cancer cells tend to agglutinate when they are concanavalin A (ConA), whereas normal cells do not. The role of ConA and similar substances has been used as a method to identify the surface of normal and deformed (or tumor) cells. In order to explain the agglutination of these substances on cells, many biologists have conducted research and description. Now Mark Willingham and Ira Pastan of the National Cancer Institute have come up with new hypotheses to directly determine why and why ConA agglutinates deformed rather than normal cells. This assumption caused great interest and controversy among the investigators.