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自 196 9年Ｒｙｇａｒｒｄ和Ｐｏｖｌｓｅｎ(Ｃｏｎ ｃｅｒＲｅｓ,1975 )首次将人结肠癌成功移植于裸鼠 ,建立裸鼠移植瘤模型以后。人们已将这一方法应用于许多肿瘤的研究 ,神经母细胞瘤也不例外。 1975年ＬａｗｒｅｎｃｅＨｅｌｓｏｎ第一次成功的将人神经母细胞瘤ＳＫ Ｎ Ｓ
Since 1996, Rygarrd and Povlsen (Con cerRes, 1975) successfully transplanted human colon cancer into nude mice for the first time. This method has been applied to the study of many tumors, neuroblastoma is no exception. 1975 LawrenceHelson first successful human neuroblastoma SKN S