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目的:探讨年龄、性别、族别及合并用药对新疆癫痫患儿左乙拉西坦(LEV)血药浓度的影响。方法:采用超高效液相色谱法(UPLC)测定110例癫痫患儿LEV的稳态血药浓度,并记录患儿的年龄、性别、族别、给药剂量及合并用药等基本信息,利用SPSS 17.0软件进行数据分析。结果:在每千克体质量给药剂量无差异的情况下,不同年龄、性别和族别癫痫患儿LEV的CDR值的差异无统计学意义(P>0.05);LEV合并丙戊酸钠(VPA)或LEV合并VPA、托吡酯(TPM)后的LEV给药剂量和血药浓度呈显著正相关(r>0.6,P<0.05),LEV单药及LEV合并VPA、奥卡西平(OXC)或拉莫三嗪(LTG)后的LEV给药剂量和血药浓度不相关。结论:LEV在儿童体内消除速率快,半衰期短,用药依从性差,且癫痫患儿需长期服药,因此在儿科临床用药时,通过对LEV的血药浓度进行监测,可为患儿提高疗效和服药依从性提供依据。
Objective: To investigate the effects of age, sex, ethnicity and combination therapy on the plasma concentration of levetiracetam (LEV) in children with epilepsy in Xinjiang. Methods: The plasma concentration of LEV in 110 children with epilepsy was determined by UPLC. The basic information such as the age, sex, ethnicity, dosage and combination medication were recorded. 17.0 software for data analysis. RESULTS: There were no significant differences in the CDR values of LEV among children of different ages, genders and families with epilepsy (P> 0.05). There was no significant difference in LEV with VPA ) Or LEV combined with VPA, topiramate (TPM) LEV dose and plasma concentration was significantly correlated (r> 0.6, P <0.05), LEV monotherapy and LEV with VPA, oxcarbazepine (OXC) There was no correlation between LEV dose and plasma concentration after moxide (LTG). Conclusions: LEV has rapid elimination rate, short half-life, poor medication compliance and long-term medication for children with epilepsy. Therefore, the monitoring of LEV blood concentration in pediatric clinical medication can improve the efficacy and medication for children Compliance to provide the basis.