【摘 要】
：
A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5- [2-(4-chlorophenoxymethylbenzimi
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5- [2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various(un)substituted aromatic acids in the presence of phosphorous oxychloride.These compounds were investigated for their inhibitory activity to E.coli methionine aminopeptidase(EcMetAP1).Some of the tested compounds showed significant inhibitory activity.
A novel series of 3,6-disubstituted 1,2,4-triazolo [3,4-b] -1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5- [2- (4-chlorophenoxymethylbenzimidazole ) -1-methylene] -3-mercapto-1,2,4-triazole with various (un) substituted aromatic acids in the presence of phosphorous oxychloride.The compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase (EcMetAP1) .Some of the tested compounds showed significant inhibitory activity.
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