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目的观察在原发高脂血症合并急性冠脉综合征早期应用辛伐他汀对降低血脂的疗效及缺血事件发生的影响。方法将48例原发高脂血症合并急性冠脉综合征(ACS)患者随机分为试验组A24例和对照组B 24例。试验组A在两组治疗常规相同基础上,每晚顿服辛伐他汀(舒降之)20 mg,疗程6周,观察用药前后血脂变化及缺血事件的发生情况。结果对照组治疗前后血脂无明显变化,试验组用药前后血脂明显下降(P<0.05),缺血事件发生率明显下降(P<0.05)。结论原发高脂血症合并急性冠脉综合征,早期每晚应用舒降之20mg降脂疗效确切及明显降低缺血事件的发生。
Objective To observe the effect of simvastatin on lipid lowering efficacy and ischemic events in patients with primary hyperlipidemia and acute coronary syndrome. Methods Forty-eight patients with primary hyperlipidemia and acute coronary syndrome (ACS) were randomly divided into experimental group A 24 and control group B 24 cases. The experimental group A was treated with Simvastatin 20 mg once daily for 6 weeks, and the changes of blood lipid and the occurrence of ischemic events were observed before and after treatment. Results Before and after treatment, there was no significant change in blood lipids in the control group. The levels of lipid in the experimental group decreased significantly (P <0.05) and the incidence of ischemic events decreased significantly (P <0.05). Conclusion Primary hyperlipidemia with acute coronary syndromes, the early night of application of antihypertensive effect of 20mg lipid-lowering effect of the exact and significantly reduce the occurrence of ischemic events.