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诱导多能干细胞(i PSCs)因其独特优势在再生医学领域具有广泛的应用前景。近年来,一系列的研究发现染色质修饰因子对于干性的维持和促进重编程进程不可或缺。在重编程过程中抑制一些染色质修饰酶能提高重编程效率,而敲减或敲除一些染色质修饰因子则使重编程效率下降或不能实现重编程。该文就近几年发现的在i PSCs重编程过程中发挥重要作用的染色质修饰因子及其作用机制予以综述。
Induced pluripotent stem cells (iPSCs) have wide application prospects in the field of regenerative medicine because of their unique advantages. In recent years, a series of studies have found that chromatin modifiers are essential for the dry maintenance and promotion of reprogramming. Inhibition of some chromatin-modifying enzymes during reprogramming increases reprogramming efficiency, while knocking-down or knock-down of some chromatin-modifying factors reduces or fails to reprogram reprogramming efficiency. This review summarizes the chromatin modifiers and their mechanisms that play an important role in the reprogramming of i PSCs in recent years.