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将９０只大鼠用醋酸铅溶液灌胃，当尿铅＞（０．８１±０．２６）ｍｇ／Ｌ，血铅＞（４．８±０．３３）ｍｇ／Ｌ时，随机分为３组，测定血清中氧化损伤的指标发现超氧化物歧化酶（ＳＯＤ）活性降低和丙二醛（ＭＤＡ）升高。用一种有机硒化合物（ＦＣＱＹ）灌胃后，ＳＯＤ活性明显升高，并有效地抑制脂质过氧化（ＭＤＡ降至正常范围）。将动物处死后，测定骨铅、肾铅和肝铅含量，发现该有机硒能干扰铅的吸收和蓄积。为铅中毒的防治提供了探讨药物治疗的信息
Ninety rats were intragastrically administrated with lead acetate solution. When the urinary lead> (0.81 ± 0.26) mg / L and blood lead> (4.8 ± 0.33) mg / L), they were randomly divided into three groups , Indicators of serum oxidative damage were found to reduce the activity of superoxide dismutase (SOD) and malondialdehyde (MDA). After intragastric administration of one organic selenium compound (FCQY), SOD activity was significantly increased and lipid peroxidation (MDA decreased to normal range) was effectively inhibited. After the animals were killed, bone lead, kidney lead and liver lead contents were determined and found that the organic selenium could interfere with lead absorption and accumulation. For the prevention and treatment of lead poisoning provides information on drug treatment