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目的 探讨99mTc TRODAT 1单光子放射计算机断层显像 (SPECT)早期诊断帕金森病 (PD)的价值。方法 分别对PD组和正常对照组进行99mTc TRODAT 1SPECT脑显像 ,使用SiemensECAMSPECT双探头。从横断面上选出基底节最清晰的一层进行相对定量分析 ,应用计算机感兴趣区 (ROI)技术在图像上分别勾划基底节 (BG)和枕叶 (OC)ROI,计算BG/OC放射性比值。结果 PD组 2 2例 ,按改良Hoehn和Yahn评分 :1级组 8例 ,1.5级组 14例 ;对照组 6例。99mTc TRODAT 1SPECT脑显像示 ,PD患者症状对侧BG受损情况明显重于症状同侧BG ,与正常对照组比较有明显的差异。BG/OC比值显示 :1级和 1.5级PD患者的症状对侧BG/OC比值均显著低于症状同侧 (P <0 .0 1) ;1.5级PD患者两侧BG/OC平均值 (1.2 0± 0 .17)与对照组 (1.5 5± 0 .12 )比较 ,差异有显著性 (P <0 .0 0 1) ;1级PD患者症状对侧BG/OC(1.34± 0 .13)与 1.5级 (1.17± 0 .16 )比较 ,差异有显著性 (P <0 .0 5 ) ;1级PD患者两侧BG/OC平均值 (1.4 0± 0 .15 )与对照组 (1.5 5± 0 .12 )比较 ,差异无显著性 (P >0 .0 5 ) ;1级与 1.5级PD患者的BG/OC平均值之间差异有显著性 (P <0 .0 5 )。正常对照组BG/OC比值显著高于PD组 (1级和 1.5级 ) (P <0 .0 0 1)。1级与 1.5级PD患者症状同侧的BG/
Objective To investigate the value of 99mTc TRODAT 1 single photon emission computed tomography (SPECT) in the early diagnosis of Parkinson’s disease (PD). Methods 99m Tc TRODAT 1 SPECT brain imaging was performed on PD group and normal control group, respectively. SiemensECAMSPECT double probe was used. From the cross-section, the clearest layer of basal ganglia was selected for relative quantitative analysis. ROI was used to map the basal ganglion (BG) and occipital lobe (ROI) respectively, and the BG / OC Radioactive ratio. Results Twenty-two patients in PD group had improved Hoehn and Yahn scores: 8 in grade 1 and 14 in grade 1.5, and 6 in control group. 99mTc TRODAT 1 SPECT brain imaging showed that the contralateral BG damage in PD patients was significantly heavier than that in the ipsilateral BG, which was significantly different from the normal control group. The ratio of BG / OC showed that the ratio of BG / OC was significantly lower in patients with grade 1 and grade 1.5 than in patients with PD (P <0. 01) (P <0.01). The level of BG / OC (1.34 ± 0.13) in the first grade PD patients was significantly higher than that in the control group (1.5 ± 0.12) Compared with 1.5 grade (1.17 ± 0.16), the difference was significant (P <0.05). The average BG / OC of both sides of grade 1 PD patients (1.4 ± 0.15) and control group (1.5 5 ± 0.12). There was no significant difference between the two groups (P> 0.05). There was a significant difference between the mean BG / OC of grade 1 and 1.5 PD patients (P <0.05). The BG / OC ratio in the normal control group was significantly higher than that in the PD group (grade 1 and grade 1.5) (P <0.001). Grade 1 and 1.5 PD patients with symptoms of ipsilateral BG /