目的:观察华蟾素注射液治疗老年晚期恶性肿瘤的疗效。方法:将68例老年晚期恶性肿瘤患者随机分为治疗组36例,对照组32例,常规对症、支持治疗,治疗组给予华蟾素注射液静脉滴注。观察两组瘤体近期疗效、Karnofsky评分及体重。结果:治疗组与对照组近期疗效无统计学差异(P>0.05),Karnofsky评分及体重明显优于对照组(P<0.05)。结论:华蟾素注射液可以改善老年晚期肿瘤的生活质量,安全性较好。 Objective: To observe the efficacy of cinobufacini injection in the treatment of advanced malignant neoplasm. Methods: Sixty-eight elderly patients with advanced malignant tumor were randomly divided into treatment group (n = 36) and control group (n = 32). Conventional symptomatic and supportive treatment was given. The treatment group was given cinobufacini injection intravenously. The curative effect, Karnofsky score and body weight of the two groups were observed. Results: There was no significant difference in the curative effect between the treatment group and the control group (P> 0.05). Karnofsky score and body weight were significantly better than those of the control group (P <0.05). Conclusion: Cinobufotalin injection can improve the quality of life of elderly patients with advanced cancer and is safe.