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将含醋酸炔诺酮1毫克,炔雌醇50微克复方炔诺酮口服避孕片改为阴道给药。受试者20名妇女(20～25岁),均有生育力,既往月经正常,受试前三个月未用任何激素类药物。周期第五天起用药,连用21天。用药前及后20天,24天取血测血中孕酮水平及血糖等生化指标,并在第24天取子宫内膜活检,询问有无副作用,共观察57个周期。结果:(1)受试者在用药前血浆孕酮平均水平约11.8ng/ml,用药后均低于3ng/ml,
The norethisterone acetate 1 mg, ethinyl estradiol 50 micrograms of compound norethisterone oral contraceptives to vaginal administration. Subjects 20 women (20 to 25 years old), are fertile, previous normal menstruation, three months before the test without any hormonal drugs. Cycle from the fifth day medication, once every 21 days. Before and 20 days after treatment and 24 days blood test blood progesterone levels and blood glucose and other biochemical indicators, and on the 24th day to take endometrial biopsy, asked whether there are any side effects, a total of 57 cycles observed. Results: (1) The average plasma progesterone level of the subjects before treatment was about 11.8ng / ml, both of which were lower than 3ng / ml after treatment,