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从双氨基甲基手性双环胍出发,经三步反应合成了由稳定的共价键桥联双环胍、氮杂冠醚和萘环的氨基酸受体1.液-液竞争萃取和~1H NMR实验表明受体对氨基酸两性离子具有较好的侧链选择性和对映选择性,能够选择性地将L-芳香族氨基酸从水相转移到二氯甲烷有机相.
Starting from bis-aminomethyl chiral bicyclic guanidine, amino acid acceptor 1 was synthesized by stable covalent bond bridged bicyclic guanidine, aza crown ethers and naphthalene ring through a three-step reaction.1 Liquid-liquid competitive extraction and ~ 1H NMR Experiments show that the acceptor has good side chain selectivity and enantioselectivity for the amino acid zwitterion and can selectively transfer the L-aromatic amino acids from the aqueous phase to the dichloromethane organic phase.