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血浆胰岛素浓度升高以及葡萄糖耐量受损通常都可见于临床与实验性甲状腺功能亢进(甲亢),糖尿病人如发生甲亢,将使其代谢状态恶化,并增加对胰岛素的需要量。为了说明这种情况,曾推测甲状腺激素可能产生胰岛素抵抗。但长期以来尚缺乏直接证据支持上述假说。本文旨在观察实验性甲亢时由胰岛素引致的葡萄糖代谢。 实验在健康志愿者(男性,20～26岁,在理想体重10％以内)使用T_4治疗前后进行(剂量为250μg/
Increased plasma insulin levels and impaired glucose tolerance are usually seen in both clinical and experimental hyperthyroidism (hyperthyroidism). Hyperthyroidism in diabetic patients will worsen the metabolic status and increase insulin requirements. To illustrate this situation, it has been speculated that thyroid hormones may produce insulin resistance. However, there is a lack of direct evidence to support this hypothesis for a long time. This article aims to observe the glucose metabolism induced by insulin in experimental hyperthyroidism. The experiment was performed before and after treatment with T 4 in healthy volunteers (men, 20-26 years of age, within 10% of ideal body weight) at a dose of 250 μg /