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氚水的致癌效应研究工作包括两部分。第一部分为体外细胞转化实验,使CHL-1细胞受氚水照射24～96h,比活度为9.25×10~5～3.5×10~6Bq/ml,累积剂量为0.055～0.88Gy。并以~(137)Csγ射线为参考射线,以恶性转化率为终点求得氚水相对于γ射线的RBE值为1.6。第二部分观察了大鼠长期(1.5a)饮用氚水,其比活度为2.22×10~5,1.11×10~5Bq/ml,对照组饮用自来水。结果表明,大剂量组的肿瘤总发病率和恶性肿瘤的发病率与小剂量组和对照组相比在统计学上有明显差异。
The research on the carcinogenic effect of drowning water includes two parts. The first part is the in vitro cell transformation experiment. The CHL-1 cells were exposed to water for 24 to 96 hours. The specific activity was 9.25×10~5~3.5×10~6Bq/ml, and the cumulative dose was 0.055~0.88Gy. Using the ~(137)Cs gamma ray as a reference beam, the RBE value of hydrophobic water relative to gamma rays was found to be 1.6 at the end of the malignant transformation rate. The second part observed the long-term drinking water (1.5a) in rats, the specific activity was 2.22×10~5, 1.11×10~5Bq/ml, and the control group was drinking tap water. The results showed that there was a statistically significant difference in the overall incidence of tumors and the incidence of malignant tumors in the high-dose group compared with the low-dose group and the control group.