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目的探讨原发性低颅压综合征(PIH)的临床特点、发病机制、脑脊液(CSF)及影像学改变。方法回顾性分析15例PIH患者的临床资料并复习文献。结果15例患者均有体位性头痛;CSF压力均小于70mmH2O,细胞数增高2例,蛋白增高9例;13例行头颅CT平扫,9例正常,2例双侧脑室系统缩小,1例慢性硬膜下血肿,1例硬膜下积液;9例行头颅MRI检查,4例硬脑膜增厚并明显强化,1例慢性硬膜下血肿,1例“脑下沉”改变。结论认识PIH的临床特点、发生机制、CSF及影像学特征,可提高PIH的确诊率;本病预后一般较好。
Objective To investigate the clinical features, pathogenesis, cerebrospinal fluid (CSF) and imaging changes of primary intracranial hypotension syndrome (PIH). Methods Retrospective analysis of 15 cases of PIH clinical data and review the literature. Results All the 15 patients had postural pain. CSF pressure was less than 70mmH2O, the number of cells increased in 2 cases and the protein increased in 9 cases. In 13 cases, skull CT scan was performed, in 9 cases was normal, in 2 cases in bilateral ventricular system was reduced, in 1 case was chronic Subdural hematoma, 1 case of subdural effusion; 9 cases of cranial MRI examination, 4 cases of dural thickening and significantly enhanced, 1 case of chronic subdural hematoma, 1 case of “brain subsidence” change. Conclusions Understanding of the clinical features, pathogenesis, CSF and imaging features of PIH can improve the diagnosis of PIH; the prognosis of this disease is generally good.