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目的探讨药物诱导的自身免疫性肝炎(DAIH)的临床特点与诊治方法。方法回顾性分析5例确诊为DAIH患者的临床资料。结果本院DAIH患者均为女性,通常在用药后6 d~24个月发病。临床表现以肝脏损害为主,并有高球蛋白血症及自身抗体阳性,多伴其他自身免疫性疾病。以糖皮质激素加用保肝降酶药联合治疗的方案可取得良好效果。结论DAIH为少见疾病,应用糖皮质激素加保肝降酶药联合治疗可改善预后。
Objective To investigate the clinical characteristics and diagnosis and treatment of drug-induced autoimmune hepatitis (DAIH). Methods The clinical data of 5 patients diagnosed as DAIH were retrospectively analyzed. Results All patients with DAIH in our hospital were female, and usually developed from 6 d to 24 months after treatment. The main clinical manifestations of liver damage, and hypergammaglobulinemia and autoantibodies, mostly with other autoimmune diseases. Glucocorticoid and liver plus enzyme combination therapy programs can achieve good results. Conclusions DAIH is a rare disease. Glucocorticoid plus hepatoprotective drug combination therapy can improve the prognosis.