论文部分内容阅读
目的探讨新西兰兔VX2肝癌MRI征象的病理学基础。方法移植法建立新西兰兔VX2肝癌模型20只共32个瘤灶。模型建立后2~4周,全部兔肝癌模型行肝脏MRI平扫,10只兔肝癌模型(包括15个瘤灶)加做MRI增强扫描。MRI检查完成后,留取肿瘤最大横截面标本,行VX2肝癌MRI征象与病理学对照研究。结果种植瘤成活率为100%。T2WI 6个瘤灶呈均匀稍高信号,其余26个瘤灶显示特征性瘤内异常信号,其中“结中结征”5个瘤灶、“靶环征”7个瘤灶、“点彩征”14个瘤灶。对照研究证实此种瘤内异常信号病理基础为不同结构类型的坏死肿瘤组织。增强后肿瘤环形强化,轻微强化6个瘤灶,中等程度强化7个瘤灶,明显强化2个瘤灶,光镜下轻微强化者强化肿瘤组织有大量点状坏死区,明显强化者瘤内血窦明显扩张。结论MRT2WI可评价坏死肿瘤组织结构类型,兔VX2肝癌肿瘤强化程度与肿瘤内血窦扩张程度及瘤内点状坏死数量有关。
Objective To investigate the pathological basis of MRI signs of VX2 liver cancer in New Zealand rabbits. Methods Twenty new tumor models of VX2 hepatocellular carcinoma were established in 20 New Zealand rabbits. Two to four weeks after model establishment, liver MRI was performed on all rabbit models of liver cancer, and 10 rabbit models of liver cancer (including 15 tumors) were scanned with MRI. MRI examination was completed, the largest cross-section of tumor specimens were taken, VX2 liver MRI signs and pathological control study. Results The survival rate of implant tumor was 100%. T2WI 6 tumor lesions showed a slightly higher signal, and the remaining 26 tumor lesions showed characteristic intra-tumor abnormal signals, including “knot junction” 5 tumor, “target ring sign” 7 tumor, “Point color levy ” 14 tumor. The control study confirmed that the abnormal signal pathology of this kind of tumor is based on the different structural types of necrotic tumor tissue. After the enhancement, the tumor was ring-shaped and slightly strengthened. Six tumors were moderately enhanced, and seven tumors were moderately enhanced. Two tumors were obviously enhanced. A slight enhancement of the tumor tissue under the light microscope resulted in a large number of punctate necrosis areas. Sinus obvious expansion. Conclusion MRT2WI can be used to evaluate the histological type of necrotic tumor. The degree of tumor enhancement in rabbit VX2 hepatocellular carcinoma is related to the degree of sinusoid expansion and the number of punctate necrosis in tumor.