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目的探讨检测尿细胞角蛋白CYFRA 21-1在诊断膀胱移行细胞癌中的价值。方法检测膀胱移行细胞癌患者与膀胱良性病变患者及健康对照组尿CYFRA 21-1的值,比较各组间的差异。结果移行细胞组尿CYFRA21-1浓度显著高于良性病变组及健康对照组,差异有高度统计学意义(P<0.001);良性病变组与健康对照组比较,差异无统计学意义(P>0.05);在移行细胞癌组中转移患者与未转移患者比较,差异亦有高度统计学意义(P<0.01)。结论尿CYFRA 21-1检测对诊断膀胱癌及其转移有一定的临床价值。
Objective To investigate the value of measuring cytokeratin CYFRA 21-1 in the diagnosis of bladder transitional cell carcinoma. Methods The urinary CYFRA 21-1 levels in patients with transitional cell carcinoma of the bladder and benign cystic lesions and healthy controls were measured and the differences between groups were compared. Results The urinary CYFRA21-1 concentration in transitional cell group was significantly higher than that in benign lesion group and healthy control group (P <0.001). There was no significant difference between benign lesion group and healthy control group (P> 0.05 ). There was also a statistically significant difference between patients with metastasis and without metastasis (P <0.01). Conclusion The urinary CYFRA 21-1 test has some clinical value in the diagnosis of bladder cancer and its metastasis.