肌萎缩侧索硬化 (AmyotrophicLateralSclerosis,ALS)是选择性侵犯上下运动神经元的神经系统变性疾病 ,病因不明 ,目前尚无有效治疗。主要的发病机制假说之一为谷氨酸中毒学说。目前已经证实肌萎缩侧索硬化存在谷氨酸代谢、摄取异常 ,认为其选择性运动神经元损伤可能是通过Ca2 + -AMPA/Kanait受体介导的兴奋性中毒发生的 ,此外运动神经元保护机制异常可能也发挥了一定作用 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively attacks the upper and lower motor neurons. The cause of the disease is unknown and there is no effective treatment. One of the main pathogenesis hypotheses is the theory of glutamate poisoning. It has been confirmed that amyotrophic lateral sclerosis has glutamate metabolism, uptake abnormalities, that selective motor neuron injury may be caused by Ca2 + -AMPA / Kanait receptor mediated excitotoxicity, in addition to motor neuron protection Abnormal mechanism may also play a role